Lecture 5 - Dose-Response Relationships

See Lecture Schedule for Delivery Date

Learning Objectives

1. Understand the quantitative relationship between toxicant exposure and induced effect.
2. Describe frequently encountered toxic effects.
3. Interpret frequency (normal distribution) and dose-response curves.
4. Understand threshold effects with dosage increase.
5. Understand effective dose, margin of safety and the relationship of effective vs. toxic dose.
6. Examine the use of actual data for no observed effect and lowest observed effect in risk assessments.
7. Summarize effective, lethal and toxic doses.
8. Understand a linearized, multi-stage model for non-threshold responses.

Advance Reading

1. Richards, pp 105-114; pp 305-331
2. NLM Toxicology Tutor Dose and Response

Resources

Keywords

Suggested Reading