Lecture 8 - Biotransformation

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Learning Objectives

1. Explain the role of biotransformation in toxicokinetics.
2. Describe how biotransformation facilitates the elimination of toxicants or their metabolites from the body.
3. Distinguish between Phase I and Phase II biotransformation reactions.
4. Define bioactivation or toxication.
5. Identify the tissues responsible for biotransformation reactions.
6. List the factors affecting biotransformation in humans.
7. Summarize the role of elimination in toxicokinetics.
8. Describe processes occurring in the kidney, liver, and lung as related to the elimination of toxicants.

Advance Reading

1. Richards, pp 139-153; pp 132-137
2. NLM Toxicology Tutor Biotransformation
3. NLM Toxicology Tutor Excretion

Resources

Keywords