Lecture 9 - Target Organ Toxicity

See Lecture Schedule for Delivery Date

Learning Objectives

1. Define target organ toxicity.
2. Explain the basis for the specificity of organ toxicity.
3. Contrast the toxicity mechanisms for hematotoxicity, hepatotoxicity, nephrotoxicity, neurotoxicity, dermatotoxicity, and pulmonotoxicity.
4. Describe examples of target organ toxicity.
5. Discuss the characteristic evaluative procedures for determining toxicity in target organs.
6. Explain the concept of oxidative stress and demonstrate an understanding of the action of antioxidant enzymes and redox cycling compounds.
7. Examine the molecular pathways of cholinesterase inhibition.

Advance Reading

1. Richards, pp 203-210; pp 213-220; pp 255-266
2. NLM Toxicology Tutor Toxic Effects-Organ Specific Toxic Effects
3. NLM Toxicology Tutor Neurotoxicity

Resources

Keywords

Suggested Reading

• American Liver Foundation - Liver Health
• National Institute of Diabetes, Digestive, and Kidney Diseases
• American Lung Association