University of Idaho foodTOX - Food Toxicology the study of Toxic Substances in the Environment
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Lecture 7 - Distribution and Storage of Toxicants

Learning Objectives

  1. Identify the ways toxicants are distributed in the body.
  2. Recognize the relationship between route of absorption and pathway for distribution.
  3. Describe factors affecting distribution.
  4. Define volume of distribution.
  5. List storage sites.
  6. Discuss how storage influences toxicant half-life.
  7. Review case studies and model of storage and distribution.

Advance Reading

  1. Hughes, pp 60-68
  2. Shibamoto, pp 11-13
  3. NLM Toxicology Tutor Distribution
  4. Enterohepatic Recirculation Animation
  5. Download, install, and survey IEUBK and LEADSPREAD computer models for blood lead.

Suggested Reading

Lecture Materials

Lecture - Podcast
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Lecture - Real Player Lecture - Slides

Lecture Activities

Keywords

  1. Adipose tissues
  2. Albumin
  3. Arterial vessels
  4. Blood flow
  5. Blood flow/ mass ratio
  6. Blood plasma
  7. Blood-brain barrier
  8. Capillaries
  9. Cardiac output
  10. Distribution
  11. Erythrocytes
  12. Heart
  13. Interstitial fluid
  14. Intracellular fluid
  
  1. Leukocytes
  2. Lymph
  3. Lymph capillaries
  4. Lymph nodes
  5. Lymphatic system
  6. Lymphocytes
  7. Lymphoid tissue
  8. Placental barrier
  9. Plasma protein
  10. Platelets
  11. Portal vein
  12. Storage
  13. Venous vessels
  14. Volume of distribution (VD)

 

Question or Comment? E-mail foodtox@uidaho.edu
 
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